Asifa Axtar sahifasining manbasini koʻrish

'''Asifa Axtar''' — pokistonlik biolog. U [[Xromosomalar|xromosomalarni]] tartibga solish sohasidagi izlanishlarga katta hissa qoʻshgan<ref>{{Veb manbasi|url=https://www.sciencedaily.com/releases/2012/07/120719141806.htm|sarlavha=What 10,000 fruit flies have to tell us about differences between the sexes|sana=19 July 2012|ish=ScienceDaily|til=en|qaralgan sana=2019-06-03}}</ref>. U Maks Plank nomidagi immunobiologiya va epigenetika institutida katta guruh rahbari va xromatinni tartibga solish boʻlimi direktori sifatida faoliyat yuritgan<ref>{{Veb manbasi|url=https://www.ie-freiburg.mpg.de/4703712/management_board|sarlavha=Management Board|ish=www.ie-freiburg.mpg.de|qaralgan sana=2019-05-11}}</ref>. Axtar 2013-yilda EMBO aʼzoligi bilan taqdirlangan<ref name=":0">{{Veb manbasi|url=http://www.embo.org/news/press-releases/2013/embo-announces-new-members-for-2013|arxivurl=https://web.archive.org/web/20160417091336/http://www.embo.org/news/press-releases/2013/embo-announces-new-members-for-2013|arxivsana=April 17, 2016|sarlavha=EMBO announces new members for 2013|ish=EMBO|qaralgan sana=2019-05-11}}</ref>. U 2020-yil iyul oyida Maks Plank jamiyatining [[biologiya]] va tibbiyot boʻlimining birinchi xalqaro ayol vitse-prezidenti boʻldi<ref>{{Veb manbasi|url=https://www.mpg.de/15105526/new-vice-presidents?fbclid=IwAR1vOYqpJXnwn7B55SCnx9Qy1ECvCoT6zrXQqYq4WowC6qnfW-nxMgaBkP0|sarlavha=New team, new Ideas|sana=1 July 2020|ish=mpg.de|til=en-us|qaralgan sana=2020-07-05}}</ref>.

== Akademik faoliyati ==
Asli [[Pokiston|Pokistonning]] [[Karachi]] shahridan boʻlgan Asifa Axtar London Universitet kollejida biologiya boʻyicha bakalavr darajasini tamomlagan va Richard Treysman laboratoriyasida transkripsiyani tartibga solish boʻyicha [[fan doktori]] maqomini olish uchun Imperial saraton tadqiqot jamgʻarmasiga (hozirgi Frensis Krik institutining bir qismi) koʻchib oʻtgan. Axtarning xromatinni tartibga solish boʻyicha postdoktorlik tadqiqotlari Piter Bekkerning [[Germaniya]] laboratoriyasida, Yevropa [[molekulyar biologiya]] laboratoriyasida (EMBL), Geydelberg va Adolf Butenandt institutida, Myunxenda oʻtkazildi. Axtar 2001 yilda EMBLda guruh rahbari boʻldi va 2009 yilda Maks Plank nomidagi Immunobiologiya va epigenetika institutiga, Frayburgga koʻchib oʻtdi va u yerda Axtar laboratoriyasini boshqaradi<ref>{{Veb manbasi|url=https://phys.org/news/2015-10-logistics-drosophila-chromosome.html|sarlavha=The logistics on the drosophila X chromosome|sana=2 October 2015|ish=phys.org|til=en-us|qaralgan sana=2019-06-03}}</ref>. Axtar – „Journal of Cell Science“ jurnalining muharriri<ref>{{Cite journal|last=Way|first1=Michael|date=2019-01-15|title=New Editor on Journal of Cell Science|journal=J Cell Sci|volume=132|issue=2|pages=jcs229740|doi=10.1242/jcs.229740|issn=0021-9533|pmid=30670474}}</ref>. 2020-yil 1-iyulda u Maks Plank jamiyatining biologiya va tibbiyot boʻlimi vitse-prezidenti etib saylandi.

Asifa Axtarning tadqiqot yoʻnalishi xromatin va epigenetik mexanizmlarni oʻrganishga qaratilgan edi. Eksperimental model sifatida Drosophila melanogasterdan foydalanib, Axtar dozaj kompensatsiyasi X xromosomasini boshqarishda qanday harakat qilishini tadqiq etgan<ref>{{Cite journal|last=Valsecchi|first1=Claudia Isabelle Keller|last2=Basilicata|first2=M. Felicia|last3=Semplicio|first3=Giuseppe|last4=Georgiev|first4=Plamen|last5=Gutierrez|first5=Noel Marie|last6=Akhtar|first6=Asifa|date=2018|title=Facultative dosage compensation of developmental genes on autosomes in Drosophila and mouse embryonic stem cells|journal=Nature Communications|volume=9|issue=1|pages=3626|bibcode=2018NatCo...9.3626V|doi=10.1038/s41467-018-05642-2|issn=2041-1723|pmc=6128902|pmid=30194291}}</ref><ref>{{Cite journal|last=Akhtar|first1=Asifa|last2=Steinmetz|first2=Lars M.|last3=Luscombe|first3=Nicholas M.|last4=Manke|first4=Thomas|last5=Raja|first5=Sunil|last6=Wei|first6=Wu|last7=Conrad|first7=Thomas|last8=Ramírez|first8=Fidel|last9=Filipe Tavares Cadete|date=June 2016|title=Functional interplay between MSL1 and CDK7 controls RNA polymerase II Ser5 phosphorylation|journal=Nature Structural & Molecular Biology|volume=23|issue=6|pages=580–589|doi=10.1038/nsmb.3233|pmid=27183194|issn=1545-9985}}</ref>. Tadqiqotlar, shuningdek, yadro RNK helikazasi DHX9 [[Genom|genomni]] transpozon kiritishning zararli taʼsiridan qanday himoya qilishiga qaratilgan<ref>{{Cite journal|last=Akhtar|first1=Asifa|last2=Backofen|first2=Rolf|last3=Manke|first3=Thomas|last4=Mittler|first4=Gerhard|last5=Pessoa Rodrigues|first5=Cecilia|last6=Bhardwaj|first6=Vivek|last7=Maticzka|first7=Daniel|last8=Ilık|first8=İbrahim Avşar|last9=Aktaş|first9=Tuğçe|date=April 2017|title=DHX9 suppresses RNA processing defects originating from the Alu invasion of the human genome|url=https://archive.org/details/nature-uk_2017-04-06_544_7648/page/115|journal=Nature|volume=544|issue=7648|pages=115–119|doi=10.1038/nature21715|pmid=28355180|issn=1476-4687|bibcode=2017Natur.544..115A}}</ref>. Yaqinda Axtar [[Transkripsiya (biologiya)|transkripsiyaning]] aniqligiga nukleosoma landshaftidagi oʻzgarishlar qanday taʼsir qilishini oʻrganib chiqdi<ref>{{Cite journal|last=Lam|first1=Kin Chung|last2=Chung|first2=Ho-Ryun|last3=Semplicio|first3=Giuseppe|last4=Iyer|first4=Shantanu S.|last5=Gaub|first5=Aline|last6=Bhardwaj|first6=Vivek|last7=Holz|first7=Herbert|last8=Georgiev|first8=Plamen|last9=Akhtar|first9=Asifa|date=2019-04-01|title=The NSL complex-mediated nucleosome landscape is required to maintain transcription fidelity and suppression of transcription noise|journal=Genes & Development|volume=33|issue=7–8|pages=452–465|doi=10.1101/gad.321489.118|issn=0890-9369|pmc=6446542|pmid=30819819}}</ref>.
== Manbalar ==
{{Manbalar}}
[[Turkum:Yashayotgan insonlar]]