Estrogen retseptorlari sahifasining manbasini koʻrish

 
[[Category:Genes on human chromosome 6]]
 

'''Estrogen retseptorlari''' ( '''ER''' ) [[Hujayra|hujayralar]] ichida joylashgan [[Proteinlar|oqsillar]] guruhi. Ular [[Estrogenlar|estrogen]] [[Gormonlar|garmoni]] ( 17b-estradiol ) tomonidan faollashtirilgan retseptorlardir . <ref name="pmid17132854">{{Cite journal|title=International Union of Pharmacology. LXIV. Estrogen receptors|journal=Pharmacological Reviews|volume=58|issue=4|pages=773–81|date=Dec 2006|pmid=17132854|doi=10.1124/pr.58.4.8}}</ref> ER ning ikkita sinfi mavjud: hujayra ichidagi retseptorlarning yadro retseptorlari oilasining a'zolari bo'lgan yadroviy estrogen retseptorlari ( ERa va ERb ) va membrana estrogen retseptorlari (mERs) ( GPER (GPR30), ER-X va G <nowiki><sub id="mwGw">q</sub></nowiki> -mER ), ular asosan [[GPCR retseptorlar|G protein bilan bog'langan retseptorlari]]. 

Estrogen tomonidan faollashtirilgandan so'ng, ER yadroga o'tishga va turli genlarning faoliyatini tartibga solish uchun DNK bilan bog'lanishga qodir (ya'ni bu DNKni bog'lovchi transkripsiya omili). Shu bilan birga, u DNK bilan bog'lanishdan mustaqil ravishda qo'shimcha funksiyalarga ega. <ref name="pmid15705661">{{Cite journal|title=Integration of the extranuclear and nuclear actions of estrogen|journal=Molecular Endocrinology|volume=19|issue=8|pages=1951–9|date=Aug 2005|pmid=15705661|pmc=1249516|doi=10.1210/me.2004-0390}}</ref>

[[Jinsiy gormonlar|Jinsiy steroid(garmon)]] uchun garmon retseptorlari sifatida ( steroid gormon retseptorlari ), ER'lar, androgen retseptorlari (AR) va progesteron retseptorlari(ayollarda ajralib chiqadigan garmon) (PR) jinsiy etilish va homiladorlikda muhim ahamiyatga ega.

== Proteomika ==
Odatda '''a''' va '''b''' deb ataladigan estrogen retseptorlarining ikki xil shakli mavjud bo'lib, ularning har biri alohida gen tomonidan kodlangan (mos ravishda ESR1 va ESR2 ). Garmon bilan faollashtirilgan estrogen retseptorlari dimerlarni hosil qiladi va bu ikki shakl ko'plab hujayra turlarida birgalikda ifodalanganligi sababli, retseptorlar ERa (a) yoki ERb (b) homodimerlari yoki ERab (ab) heterodimerlarini hosil qilishi mumkin. <ref name="pmid15314175">{{Cite journal|title=Single-chain estrogen receptors (ERs) reveal that the ERalpha/beta heterodimer emulates functions of the ERalpha dimer in genomic estrogen signaling pathways|url=https://archive.org/details/sim_molecular-and-cellular-biology_2004-09_24_17/page/7680|journal=Molecular and Cellular Biology|volume=24|issue=17|pages=7681–94|date=Sep 2004|pmid=15314175|pmc=506997|doi=10.1128/MCB.24.17.7681-7694.2004}}</ref> Estrogen retseptorlari alfa va beta muhim umumiy ketma-ketlik homologiyasini ko'rsatadi va ikkalasi ham A/B dan F gacha bo'lgan beshta domendan iborat (N-dan C-terminusgacha sanab o'tilgan; [[Aminokislotalar|aminokislotalarning]] tartib raqamlari inson ERga tegishli).