Estrone (dori) sahifasining manbasini koʻrish

'''Estron''' ( '''E1''' ), '''Estragyn''', '''Kestrin''' va '''Theelin''' brendlari ostida sotiladi, menopauza (jinsiy bezlar faoliyatining  to'xtashi)gormonlarini davolashda va boshqalarda qo'llaniladigan estrogen(ayollik garmoni) dori va tabiiy ravishda paydo bo'lgan steroid gormonidir .<ref name="pmid16112947">{{Jurnal manbasi|title=Pharmacology of estrogens and progestogens: influence of different routes of administration|journal=Climacteric|volume=8 Suppl 1|pages=3–63|year=2005|pmid=16112947|doi=10.1080/13697130500148875|url=http://hormonebalance.org/images/documents/Kuhl%2005%20%20Pharm%20Estro%20Progest%20Climacteric_1313155660.pdf}}</ref><ref name="Elks2014">{{Kitob manbasi|last=J. Elks|title=The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies|url=https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA899|date=14 November 2014|publisher=Springer|isbn=978-1-4757-2085-3|pages=899–}}</ref><ref name="IndexNominum2000">{{Kitob manbasi|title=Index Nominum 2000: International Drug Directory|url=https://books.google.com/books?id=5GpcTQD_L2oC&pg=PA407|year=2000|publisher=Taylor & Francis|isbn=978-3-88763-075-1|pages=407–}}</ref><ref name="MortonHall2012">{{Kitob manbasi|last=I.K. Morton|title=Concise Dictionary of Pharmacological Agents: Properties and Synonyms|url=https://books.google.com/books?id=tsjrCAAAQBAJ&pg=PA207|date=6 December 2012|publisher=Springer Science & Business Media|isbn=978-94-011-4439-1|pages=207–}}</ref><ref name="Martindale">{{Kitob manbasi|editor=Sweetman, Sean C.|chapter=Sex hormones and their modulators|title=Martindale: The Complete Drug Reference|edition=36th|year=2009|page=2101|publisher=Pharmaceutical Press|location=London|isbn=978-0-85369-840-1|url=https://www.medicinescomplete.com/mc/martindale/2009/9092-j.htm}}</ref><ref name="GuoHahn2000">{{Kitob manbasi|last=Guo|first=J. Z.|title=Kirk-Othmer Encyclopedia of Chemical Technology|chapter=Hormones, Estrogens and Antiestrogens|year=2000|doi=10.1002/0471238961.05192018072115.a01|isbn=0471238961}}</ref> U mushak ichiga inyeksiya yo'li bilan beriladigan [[Suspenziya|suvli suspenziya]] yoki [[Moy|moyli eritma]] sifatida va vagina ichiga surtiladigan vaginal krem sifatida taqdim etilgan.<ref name="Martindale" /><ref name="GuoHahn2000" /><ref name="Speroff2015">{{Kitob manbasi|last=Speroff|first=Leon|title=Women's Hormonal Health Issues|year=2015|pages=341–354|doi=10.1007/978-3-319-13832-9_28|isbn=978-3-319-13831-2}}</ref><ref name="HelmsQuan2006">{{Kitob manbasi|last=Richard A. Helms|title=Textbook of Therapeutics: Drug and Disease Management|url=https://books.google.com/books?id=aVmRWrknaWgC&pg=PA397|year=2006|publisher=Lippincott Williams & Wilkins|isbn=978-0-7817-5734-8|pages=397–}}</ref> Bundan tashqari, og'iz orqali estradiol/estron/estriol (brend nomi '''Hormonin''') va estropipat ( estron sulfat ; '''Ogen''' markasi) va konjugatsiyalangan estrogenlar (asosan estron sulfat; brend nomi '''Premarin''') kabi oldingi dorilar shaklida ham olinishi mumkin.<ref name="pmid16112947" /><ref name="GuoHahn2000" /><ref name="Buchsbaum2012">{{Kitob manbasi|last=H.J. Buchsbaum|title=The Menopause|url=https://books.google.com/books?id=z0LuBwAAQBAJ&pg=PA64|date=6 December 2012|publisher=Springer Science & Business Media|isbn=978-1-4612-5525-3|pages=60, 62, 64}}</ref>

Estrogen kabi estrogenlarning nojo'ya ta'sirlari orasida ko'krakning nozikligi, kengayishi, [[Bosh ogʻrigʻi|bosh og'rig'i]], ko'ngil aynishi, suyuqlikni ushlab turish va shish va boshqalar uchrab turadi.<ref name="pmid16112947"/> Estron tabiiy ravishda paydo bo'lgan va biologik o'xshash estrogen yoki estrogen retseptorlarining teskarisi, [[Endogenez (biologiya)|endogen]] estradiol kabi [[estrogenlar]]ning biologik maqsadi.<ref name="pmid16112947" /> Bu nisbatan zaif estrogen bo'lib, estradiolga qaraganda ancha past faollikka ega.<ref name="pmid16112947" /> Shu bilan birga, estron organizmda estradiolga aylanadi, bu uning estrogenik kuchining ko'p qismini yoki barchasini ta'minlaydi.<ref name="pmid16112947" /><ref name="FishmanMartucci1980">{{Kitob manbasi|last=Fishman|first=J.|chapter=New Concepts of Estrogenic Activity: the Role of Metabolites in the Expression of Hormone Action|pages=[https://archive.org/details/menopausepostmen0000unse/page/43 43]–52|doi=10.1007/978-94-011-7230-1_5|editor=N. Pasetto|title=The Menopause and Postmenopause|url=https://archive.org/details/menopausepostmen0000unse|isbn=978-94-011-7232-5|year=1980}}</ref> Shunday qilib, estron estradiolning oldingi dorisidir.<ref name="pmid16112947" />

Estrone birinchi marta 1929-yilda kashf etilgan va ko'p o'tmay tibbiy foydalanish uchun kiritilgan.<ref name="Bullough1995">{{Kitob manbasi|last=Vern L. Bullough|title=Science In The Bedroom: A History Of Sex Research|url=https://books.google.com/books?id=Z7__qJK470AC&pg=PA128|date=19 May 1995|publisher=Basic Books|isbn=978-0-465-07259-0|pages=128–|quote=When Allen and Doisy heard about the [Ascheim-Zondek test for the diagnosis of pregnancy], they realized there was a rich and easily handled source of hormones in urine from which they could develop a potent extract. [...] Allen and Doisy's research was sponsored by the committee, while that of their main rival, Adolt Butenandt (b. 1903) of the University of Gottingen was sponsored by a German pharmaceutical firm. In 1929, both terms announced the isolation of a pure crystal female sex hormone, estrone, in 1929, although Doisy and Allen did so two months earlier than Butenandt.27 By 1931, estrone was being commercially produced by Parke Davis in this country, and Schering-Kahlbaum in Germany. Interestingly, when Butenandt (who shared the Nobel Prize for chemistry in 1939) isolated estrone and analyzed its structure, he found that it was a steroid, the first hormone to be classed in this molecular family.}}{{Oʻlikhavola|date=fevral 2023 |bot=InternetArchiveBot |fix-attempted=yes }}</ref><ref name="pmid18744783">{{Jurnal manbasi|title=Estrogenic Hormones: Their Clinical Usage|journal=Cal West Med|volume=49|issue=5|pages=362–6|date=November 1938|pmid=18744783|pmc=1659459}}</ref><ref name="Watkins2007">{{Kitob manbasi|last=Elizabeth Siegel Watkins|title=The Estrogen Elixir: A History of Hormone Replacement Therapy in America|url=https://books.google.com/books?id=-tz4J4_hgdIC&pg=PA21|date=6 March 2007|publisher=JHU Press|isbn=978-0-8018-8602-7|pages=21–}}</ref> O'tmishda u klinik jihatdan qo'llanilgan bo'lsa-da, estron asosan to'xtatilgan va asosan hozir sotilmaydi.<ref name="IndexNominum2000"/><ref name="Drugs.com">{{Veb manbasi|url=https://www.drugs.com/international/estrone.html|sarlavha=Estrone - Drugs.com|qaralgan sana=21 June 2018|arxivsana=21 June 2018|arxivurl=https://web.archive.org/web/20180621143924/https://www.drugs.com/international/estrone.html}}</ref>

{{Turkumsiz|date=Aprel 2024}}