Plazomitsin sahifasining manbasini koʻrish

{{Dori|licence_EU=<!-- EMA uses INN (or special INN_EMA) -->|licence_US=Zemdri|pregnancy_AU=<!-- A/B1/B2/B3/C/D/X -->|legal_AU=<!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->|legal_CA=<!-- OTC, Rx-only, Schedule I, II, III, IV, V, VI, VII, VIII -->|legal_UK=<!-- GSL, P, POM, CD, CD Lic, CD POM, CD No Reg POM, CD (Benz) POM, CD (Anab) POM or CD Inv POM / Class A, B, C -->|legal_US=Rx-only|legal_status=<!--For countries not listed above-->

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'''Zemdri''' brendi ostida sotiladigan '''plazomitsin''' [[Siydik yo'llari infeksiyasi|siydik yo'llarining infektsiyalarini]] davolashda qo'llaniladigan [[Aminoglikozidlar|aminoglikozid antibiotikidir]]<ref name="AHFS2019">{{Veb manbasi|sarlavha=Plazomicin Sulfate Monograph for Professionals|url=https://www.drugs.com/monograph/plazomicin-sulfate.html|ish=Drugs.com|nashriyot=American Society of Health-System Pharmacists|qaralgan sana=10 October 2019}}</ref>. 2019-yilda aniq  varianti bo'lmaganlar uchun tavsiya etilgan<ref name="AHFS2019" />. Vena ichiga in'ektsiya yo'li bilan yuboriladi<ref name="AHFS2019" />.

Umumiy nojo'ya ta'sirlar orasida [[Buyrak yetishmovchiligi|buyrak muammolari]], [[Ich ketishi|diareya]], ko'ngil aynishi va qon bosimining o'zgarishi kiradi<ref name="AHFS2019"/> .Boshqa jiddiy qo' shimcha ta'sirlar orasida eshitish qobiliyatining yo'qolishi, ''Clostridium difficile'' bakteriyasi bilan bog'liq diareya, [[anafilaksiya]] va muskullarl kuchsizligi ham bor. Homiladorlik paytida foydalanish chaqaloqqa zarar yetkazishi mumkin<ref name="AHFS2019" /> .Plazomitsin bakteriyalarning oqsil hosil qilish qobiliyatini kamaytirishi orqali ishlaydi.<ref name="AHFS2019" />

Plazomitsin 2018-yilda Qo'shma Shtatlarda tibbiy foydalanish uchun tasdiqlangan<ref name="FDA Zemdri 210303">{{Veb manbasi|url=https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&varApplNo=210303|sarlavha=FDA Approved Drug Products: Zemdri|ish=U.S. [[Food and Drug Administration]]|qaralgan sana=2018-06-28}}</ref><ref>{{Veb manbasi|sarlavha=Drug Approval Package: Zemdri (plazomicin)|ish=U.S. [[Food and Drug Administration]]|sana=5 July 2018|url=https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/210303Orig1s000TOC.cfm|qaralgan sana=25 December 2019|arxivsana=2020-11-28|arxivurl=https://web.archive.org/web/20201128083016/https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/210303Orig1s000TOC.cfm}}</ref> .U Jahon sog'liqni saqlash tashkilotining asosiy dorilar ro'yxatiga kiritilgan<ref name="WHO21st">{{Kitob manbasi|title=World Health Organization model list of essential medicines: 21st list 2019|year=2019|authorlink=World Health Organization|publisher=World Health Organization|location=Geneva|id=WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO}}</ref>.

== Tibbiyotda foydalanilishi ==
Plazomitsin AQSh [[oziq-ovqat va farmatsevtika idorasi]] tomonidan davolash imkoniyatlari cheklangan yoki umuman mavjud bo'lmagan bemorlarda ''Escherichia coli'', ''Klebsiella pneumoniae'', ''Proteus mirabilis'' yoki ''Enterobacter cloacae bakteriyalari'' sabab bo'luvchi pyelonefritni o'z ichiga olgan murakkab siydik yo'llari infektsiyalari kasalligi bo'lgan kattalar uchun tavfsiya etiladi. Zemdri tomir ichiga yuboriladigan infuzion bo'lib, kuniga bir marta yuboriladi<ref name="Zemdri label">{{Veb manbasi|sarlavha=Zemdri (plazomicin)- plazomicin injection|ish=DailyMed|sana=30 July 2020|url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=eccf9fd9-53ac-4252-a106-5567b3a82a70|qaralgan sana=11 October 2020}}</ref><ref>{{Veb manbasi|url=https://reference.medscape.com/drug/zemdri-plazomicin-1000230|sarlavha=plazomicin (Rx)|ish=[[Medscape]]|qaralgan sana=14 September 2019}}</ref><ref>{{Veb manbasi|sarlavha=FDA Panel Recommends Plazomicin for cUTI but Not BSI|ism=Troy|muallif=Brown|sana=3 May 2018|ish=Medscape|url=http://www.medscape.com/viewarticle/896116|qaralgan sana=14 September 2019}}</ref>.Ko'rsatigan  samaradorlikning yo'qligi sababli qon oqimi infektsiyalarini davolash uchun ruxsat rad etilgan<ref name="FDA Zemdri 210303"/>.Ko'rsatilgan samaradorlikning yo'qligi antibiotik samarasizligi bilan bog'liq emas, balki tadqiqotga kirish darajasi past edi. Sichqoncha modellari yordamida olib borilayotgan tadqiqotlar tirik qolishning yuqori darajasini belgiladi<ref>https://www.fda.gov/media/113289/download</ref>.

Plazomitsin daptomitsin yoki [[Seftobiprol|seftobiprole]] bilan metitsillinga chidamli ''Staphylococcus aureus'', vankomitsinga chidamli ''S. aureus'' va ''Pseudomonas aeruginosa'' ga qarshi [[sefepim]], doripenemitsillin yoki doripenem piperaz bilan biog'langanda ''hujayra ichiga'' sinergik faollikni ko'rsatishi haqida xabar berilgan<ref name="Zhanel">{{Cite journal|display-authors=3|title=Comparison of the Next-Generation Aminoglycoside Plazomicin to Gentamicin, Tobramycin and Amikacin|journal=Expert Review of Anti-Infective Therapy|date=April 2012|volume=10|issue=4|pages=459–73|doi=10.1586/eri.12.25|pmid=22512755}}</ref>. Shuningdek, u karbapenemga chidamli ''Acinetobacter baumannii  bakteriyasiga'' nisbatan kuchli ''hujayra ichi'' faolligini ko'rsatadi<ref>{{Cite journal|display-authors=3|title=Can Plazomicin Alone or in Combination Be a Therapeutic Option against Carbapenem-Resistant ''Acinetobacter baumannii''?|journal=Antimicrob Agents Chemother|date=October 2015|volume=59|issue=10|pages=5959–66|doi=10.1128/AAC.00873-15|url=|pmid=26169398|pmc=4576036}}</ref>. Plazomitsin meropenemdan kam emasligi aniqlandi <ref>{{Cite journal|display-authors=3|title=Once-Daily Plazomicin for Complicated Urinary Tract Infections|journal=New England Journal of Medicine|volume=380|issue=8|date=21 February 2019|issn=0028-4793|doi=10.1056/nejmoa1801467|pages=729–740|pmid=30786187}}
</ref>.

== Tarixi ==
Preparat [[Achaogen]] biotexnologik kompaniyasi tomonidan ishlab chiqarilgan. 2012-yilda AQSh oziq-ovqat va farmatsevtika idorasi plazomitsinni ishlab chiqish va tartibga solishni tekshirish uchun tezkor belgini bergan<ref>{{Pres-reliz manbasi |title=Achaogen Announces Plazomicin Granted QIDP Designation by FDA |url=https://globenewswire.com/news-release/2015/01/08/695854/10114610/en/Achaogen-Announces-Plazomicin-Granted-QIDP-Designation-by-FDA.html |publisher=[[Achaogen, Inc.]] |date=8 January 2015 |access-date=27 April 2016}}</ref> .2018 yilda plazomitsinni 2018 yilda murakkab UTI kasalligi bilan kasallangan va davolanish imkoniyatlari cheklangan yoki umuman bo'lmagan kattalar uchun tasdiqlangan<ref name="Zemdri label"/>. Achaogen dori uchun mustahkam bozor topilmadi va bir necha oydan keyin bankrotlik e'lon qilindi<ref>{{Yangiliklar manbasi |last=Jacobs |first=Andrew |name-list-style=vanc |date=25 December 2019 |title=Crisis Looms in Antibiotics as Drug Makers Go Bankrupt |work=[[The New York Times]] |url=https://www.nytimes.com/2019/12/25/health/antibiotics-new-resistance.html}}</ref> .Umumiy versiya Cipla USA tomonidan ishlab chiqarilgan<ref>{{Veb manbasi|sarlavha=Generic Zemdri Availability|url=https://www.drugs.com/availability/generic-zemdri.html|ish=Drugs.com|qaralgan sana=26 December 2019|til=en}}</ref>.

== Sintezlanilishi ==


U sisomisindan gidroksi-aminobutirik kislota o'rnini 1-pozitsiyada va gidroksietil o'rnini 6 holatida qo'shish orqali sintezlanadi<ref>{{Cite journal|display-authors=3|title=Synthesis and Spectrum of the Neoglycoside ACHN-490|journal=Antimicrob Agents Chemother|date=November 2010|volume=54|issue=11|pages=4636–4642|doi=10.1128/AAC.00572-10|url=https://archive.org/details/sim_antimicrobial-agents-and-chemotherapy_2010-11_54_11/page/4636|pmid=20805391|pmc=2976124}}</ref><ref name="Zhanel"/>. Ikkinchisi uning eng keng tarqalgan aminoglikozid atsetiltransferaza 6'-N- tip Ib (AAC(6')-Ib) tomonidan deaktivatsiyaga chidamli qiladi<ref>{{Cite journal|last=Cox|first1=Georgina|last2=Ejim|first2=Linda|last3=Stogios|first3=Peter J.|last4=Koteva|first4=Kalinka|last5=Bordeleau|first5=Emily|last6=Evdokimova|first6=Elena|last7=Sieron|first7=Arthur O.|last8=Savchenko|first8=Alexei|last9=Serio|first9=Alisa W.|title=Plazomicin Retains Antibiotic Activity against Most Aminoglycoside Modifying Enzymes|journal=ACS Infectious Diseases|date=8 June 2018|volume=4|issue=6|pages=980–987|doi=10.1021/acsinfecdis.8b00001|pmid=29634241|pmc=6167752}}</ref>.

== Nomlanishi ==
Plazomitsin xalqaro nodavlat nomi (INN)<ref>{{Cite journal|title=International Nonproprietary Names for Pharmaceutical Substances (INN). Recommended INN: List 68|journal=WHO Drug Information|volume=26|issue=3|date=September 2012|url=https://www.who.int/medicines/publications/druginformation/issues/DrugInformation2012_Vol26-3/en/|archiveurl=https://web.archive.org/web/20141002045030/http://www.who.int/medicines/publications/druginformation/issues/DrugInformation2012_Vol26-3/en/|archivedate=2 October 2014|publisher=[[World Health Organization]]|access-date=27 April 2016|page=314}}</ref>.

== Manbalar ==
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== Qo'shimcha adabiyotlar ==

* {{Veb manbasi|sarlavha=FDA Briefing Information for the May 2, 2018 Meeting of the Antimicrobial Drugs Advisory Committee|url=https://www.fda.gov/media/113161/download|nashriyot=U.S. [[Food and Drug Administration]]|sana=2 May 2018|qaralgan sana=14 September 2019|format=PDF}}
* {{Veb manbasi|sarlavha=Achaogen Briefing Information for the May 2, 2018 Meeting of the Antimicrobial Drugs Advisory Committee|url=https://www.fda.gov/media/113190/download|nashriyot=U.S. [[Food and Drug Administration]]|sana=2 May 2018|qaralgan sana=14 September 2019|format=PDF}}
* {{Veb manbasi|sarlavha=Errata to the Achaogen Briefing Information for the May 2, 2018 Meeting of the Antimicrobial Drugs Advisory Committee|url=https://www.fda.gov/media/113196/download|nashriyot=U.S. [[Food and Drug Administration]]|sana=2 May 2018|qaralgan sana=14 September 2019|format=PDF}}

== Havolalar ==

* {{Veb manbasi|url=https://druginfo.nlm.nih.gov/drugportal/name/plazomicin|nashriyot=U.S. National Library of Medicine|ish=Drug Information Portal|sarlavha=Plazomicin}}
* {{Veb manbasi|url=https://druginfo.nlm.nih.gov/drugportal/name/plazomicin%20sulfate|nashriyot=U.S. National Library of Medicine|ish=Drug Information Portal|sarlavha=Plazomicin sulfate}}
[[Turkum:Dorilar]]
[[Turkum:Aminoglikozidlar]]